In the U.S.-Mexico context, the concepts of the border, borderlands, and la frontera represent their ongoing complex geopolitical, cultural, and historical relations. With the signing of the Guadalupe Hidalgo Treaty in 1848 and the Gadsden Purchase in 1853, the Mexican and U.S. governments established the southern border of the United States. The border is the international boundary line between the two countries, and the borderlands are the zones neighboring both sides of that boundary. It is a place where the First and Third Worlds collide daily, creating borderlands that amount to collective spaces of transcultural/transnational encounters. The concept of la frontera represents a counter-narrative of the term “frontier,” which became synonymous with American expansionism, or the westward expansion of the United States as proclaimed by Frederick Jackson Turner in 1883. The Spanish term “frontera,” as used in this framework, presupposes a knowledge production ranging from the implications of land annexation to the geopolitical and cultural processes of borderland sites. While the borders mark the place where adjacent jurisdictions, communities, and nation-states meet, it has also been a hotly contested subject—literally and figuratively speaking—inciting extreme emotional reactions that fuel negative stereotypes about immigrants, ethnic discrimination, and xenophobia. Immigration has become one of the most salient sociopolitical issues discussed on the national level. Unfortunately, it is debated mainly outside of the historical context because the histories embedded in its borderlands can contribute enormously to inform current political debates about immigration in the United States. Border crossers coming from south of the border are often portrayed by U.S. politicians as the most unwelcome and undesirable (yet necessary) immigrants. As the national discussion on immigration reform continues and the alleged ills of the U.S.-Mexico border dominate the political discourse and the media, expressive art and print culture must continue to form novel epistemologies of borders and counter unsubstantiated alternative facts propagated by anti-immigrant groups. To that end, it is important to consider the border's literature and imagine the borderlands as the fruitful heterogeneous site of an imagined and creative homeland: Aztlán.